About Enhancer
| Enhancer ID: | E_03982 |
| Species: | Mus musculus |
| Position : | chr1:95932003-95932042   |
| Year: | 2014 |
| Title: | STAT3, STAT4, NFATc1, and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 24711622 |
| Tissue: | spleen |
| Tissue Ontology ID: | UBERON:0002106 |
| Cell Source: | Primary splenic CD8 T cells |
| Cell Type: | CD8-positive, alpha-beta T cell |
| Cell Ontology ID: | CL:0000625 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay |
| High Throughput Method: | Published STAT ChIP-seq data analysis |
| Low Throughput Method: | DNase I hypersensitivity assay; ChIP-qPCR; Luciferase reporter assay; STAT-site mutagenesis; 3C; RT-qPCR |
About Target Gene
| Target gene : | Pdcd1 |
About TF
| TF name : | Stat4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Stat4 | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| Stat4 | EGF receptor signaling pathway | panther | 109 |
| Stat4 | Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 14 |
| Stat4 | Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 8 |
| Stat4 | Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 8 |
| Stat4 | IL-12 signaling pathway(JAK2 TYK2 STAT4) ( IL-12 signaling(JAK2 TYK2 STAT4) ) | inoh | 7 |
| Stat4 | IL-23 signaling pathway(JAK2 TYK2 STAT3 STAT4) ( IL-23 signaling(JAK2 TYK2 STAT3 STAT4) ) | inoh | 6 |
| Stat4 | IL12-mediated signaling events | pid | 62 |
| Stat4 | IL12 signaling mediated by STAT4 | pid | 33 |
| Stat4 | IL2 | netpath | 81 |
| Stat4 | IL23-mediated signaling events | pid | 37 |
| Stat4 | IL27-mediated signaling events | pid | 26 |
| Stat4 | Interleukin signaling pathway | panther | 86 |
| Stat4 | JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 97 |
| Stat4 | JAK/STAT signaling pathway | panther | 15 |
| Stat4 | PDGF signaling pathway | panther | 113 |
| Stat4 | Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 178 |
| Stat4 | TCR | netpath | 261 |
| Stat4 | TSLP | netpath | 24 |
| Stat4 | Jak-STAT signaling pathway | kegg | 149 |
| Stat4 | Hs_Interferon_type_I_signaling_pathways_WP585_85198 | wikipathways | 35 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer