About Enhancer
| Enhancer ID: | E_03991 |
| Species: | Homo sapiens |
| Position : | chr19:151500000-152500000   |
| Year: | 2023 |
| Title: | Enhancer remodeling activates NOTCH3 signaling to confer chemoresistance in advanced nasopharyngeal carcinoma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | nasopharyngeal carcinoma |
| PMID: | 37563118 |
| MONDO: | MONDO:0015459 |
| Tissue: | nasopharynx |
| Tissue Ontology ID: | UBERON:0001728 |
| Cell Source: | CNE-2 |
| CVCL ID: | CVCL_6889 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay; In vivo functional validation |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | ChIP-RT-qPCR, RT-RT-qPCR, Western blot; In vivo phenotyping |
About Target Gene
| Target gene : | NOTCH3 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer