About Enhancer
| Enhancer ID: | E_03993 |
| Species: | Mus musculus |
| Position : | chr15:63865799-63896492   |
| Year: | 2017 |
| Title: | ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. |
| Genome Build: | mm10 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | Colon Cancer |
| PMID: | 27941798 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT 116 |
| CVCL ID: | CVCL_0291 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | TF-binding/chromatin assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | Arid1a |
About TF
| TF name : | Arid1a |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Arid1a | RMTs methylate histone arginines | reactome | 75 |
| Arid1a | Wnt signaling pathway | panther | 250 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03557 | chr15:63714919-63952099 | blood / hematopoietic system | NA | Leukaemia |
| E_03994 | chr15:63865799-63896492 | colon | malignant cell | Colon Cancer |
| E_03995 | chr15:63894512-63932136 | colon | malignant cell | Colon Cancer |
| E_03996 | chr15:63894512-63932136 | colon | malignant cell | Colon Cancer |
Expression of Target Genes for the Enhancer