About Enhancer
| Enhancer ID: | E_04003 |
| Species: | Homo sapiens |
| Position : | chr1:47704791-47705107   |
| Year: | 2019 |
| Title: | Eradication of Central Nervous System Leukemia of T-Cell Origin with a Brain-Permeable LSD1 Inhibitor. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | Central Nervous System Leukemia |
| PMID: | 30518632 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | T-acute lymphoblastic leukemia (T-ALL) |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | TF-binding/chromatin assay; In vivo functional validation; Disease-associated enhancer analysis |
| Low Throughput Method: | ChIP-qPCR/ChIP; RT-qPCR/qPCR; Transgenic/LacZ assay |
About Target Gene
| Target gene : | TAL1 |
About TF
| TF name : | ZEB2 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ZEB2 | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
16 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02300 | chr1:47679000-47722000 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_00713 | chr1:47704954-47704983 | blood | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00715 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00716 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00717 | chr1:47704954-47704983 | blood | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00718 | chr1:47704954-47704983 | blood | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00719 | chr1:47704954-47704983 | blood | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00720 | chr1:47704954-47704983 | blood | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00721 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00722 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00723 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00724 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00725 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00726 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00727 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00728 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer