About Enhancer
| Enhancer ID: | E_04041 |
| Species: | Homo sapiens |
| Position : | chr10:63525013-63527013   |
| Year: | 2017 |
| Title: | ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 29326336 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | T-acute lymphoblastic leukemia (T-ALL) |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIA-PET |
| Low Throughput Method: | CRISPR-Cas9 targeted editing/deletion |
About Target Gene
| Target gene : | ARID5B |
About TF
| TF name : | TAL1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03180 | chr10:63525013-63527013 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03181 | chr10:63525013-63527013 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03182 | chr10:63525013-63527013 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_04096 | chr10:63525013-63527013 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer