About Enhancer
| Enhancer ID: | E_04062 |
| Species: | Homo sapiens |
| Position : | chr8:128413136-128414674   |
| Year: | 2016 |
| Title: | 4C-seq revealed long-range interactions of a functional enhancer at the 8q24 prostate cancer risk locus. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 26934861 |
| MONDO: | MONDO:0008315 |
| Tissue: | prostate gland |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | LNCaP |
| CVCL ID: | CVCL_0395 |
| Cell Type: | epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Chromatin interaction assay; Enhancer activity assay; Genetic risk regulatory analysis; Disease-variant functional analysis |
| High Throughput Method: | 4C-seq; Public ChIP-seq and epigenomic data integration; GWAS |
| Low Throughput Method: | Luciferase Reporter Assay; Transgenic Reporter Assay; 4C |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | TCF7L2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TCF7L2 | Alzheimer disease-presenilin pathway | panther | 98 |
| TCF7L2 | Angiogenesis | panther | 141 |
| TCF7L2 | AP-1 transcription factor network | pid | 71 |
| TCF7L2 | Binding of TCF/LEF:CTNNB1 to target gene promoters | reactome | 7 |
| TCF7L2 | Ca2+ pathway | reactome | 62 |
| TCF7L2 | Cadherin signaling pathway | panther | 147 |
| TCF7L2 | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 |
| TCF7L2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| TCF7L2 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| TCF7L2 | ID | netpath | 38 |
| TCF7L2 | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 |
| TCF7L2 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| TCF7L2 | Repression of WNT target genes | reactome | 14 |
| TCF7L2 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| TCF7L2 | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| TCF7L2 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| TCF7L2 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | reactome | 20 |
| TCF7L2 | Wnt | netpath | 118 |
| TCF7L2 | Wnt signaling pathway | panther | 250 |
| TCF7L2 | Wnt signaling pathway | kegg | 135 |
| TCF7L2 | Adherens junction | kegg | 70 |
| TCF7L2 | Melanogenesis | kegg | 100 |
| TCF7L2 | Pathways in cancer | kegg | 321 |
| TCF7L2 | Colorectal cancer | kegg | 63 |
| TCF7L2 | Endometrial cancer | kegg | 52 |
| TCF7L2 | Prostate cancer | kegg | 85 |
| TCF7L2 | Acute myeloid leukemia | kegg | 53 |
| TCF7L2 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
11 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04111 | chr8:128412386-128415392 | prostate gland | malignant cell | prostate cancer |
| E_04112 | chr8:128412386-128415392 | prostate gland | malignant cell | prostate cancer |
| E_04113 | chr8:128412386-128415392 | prostate gland | malignant cell | prostate cancer |
| E_03718 | chr8:128412536-128414073 | colon | malignant cell | colorectal carcinoma |
| E_03347 | chr8:128413174-128414429 | colon | epithelial cell | colorectal cancer |
| E_05003 | chr8:128413174-128414429 | colon | malignant cell | colorectal carcinoma |
| E_05004 | chr8:128413174-128414429 | colon | malignant cell | colorectal carcinoma |
| E_05005 | chr8:128413174-128414429 | colon | malignant cell | colorectal carcinoma |
| E_05006 | chr8:128413174-128414429 | colon | malignant cell | colorectal carcinoma |
| E_05007 | chr8:128413174-128414429 | colon | malignant cell | colorectal carcinoma |
| E_05008 | chr8:128413174-128414429 | colon | malignant cell | colorectal carcinoma |
Expression of Target Genes for the Enhancer