About Enhancer
| Enhancer ID: | E_04088 |
| Species: | Mus musculus |
| Position : | chr5:147263197-147264197   |
| Year: | 2008 |
| Title: | Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 19141476 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | pancreatic primordium / pancreatic epithelium |
| Cell Type: | pancreatic progenitor cell |
| Experiment Type: | Developmental enhancer occupancy; conditional TF knockout; target-gene expression analysis |
| High Throughput Method: | Foxa1/Foxa2 ChIP-seq / genome-scale occupancy profiling |
| Low Throughput Method: | ChIP-qPCR; conditional knockout; RT-qPCR; immunostaining; developmental phenotyping |
About Target Gene
| Target gene : | Pdx1 |
About TF
| TF name : | Foxa1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Foxa1 | AndrogenReceptor | netpath | 167 |
| Foxa1 | Direct p53 effectors | pid | 141 |
| Foxa1 | FOXA1 transcription factor network | pid | 45 |
| Foxa1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Foxa1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04089 | chr5:147263197-147264197 | pancreas | pancreatic progenitor cell | NA |
| E_04090 | chr5:147263567-147264052 | pancreas | pancreatic progenitor cell | NA |
| E_04091 | chr5:147263567-147264052 | pancreas | pancreatic progenitor cell | NA |
| E_04080 | chr5:147263601-147264086 | pancreas | NA | NA |
| E_04081 | chr5:147263601-147264086 | pancreas | NA | NA |
Expression of Target Genes for the Enhancer