About Enhancer
| Enhancer ID: | E_04090 |
| Species: | Mus musculus |
| Position : | chr5:147263567-147264052   |
| Year: | 2008 |
| Title: | Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 19141476 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | E14.5 fetal pancreas |
| Cell Type: | pancreatic progenitor cell |
| Experiment Type: | TF binding assay; Developmental functional perturbation assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Foxa2 ChIP-qPCR; pancreas-specific Foxa1/Foxa2 conditional knockout; RT-qPCR; immunohistochemistry; in situ hybridization |
About Target Gene
| Target gene : | Pdx1 |
About TF
| TF name : | Foxa2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Foxa2 | FOXA1 transcription factor network | pid | 45 |
| Foxa2 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Foxa2 | Hedgehog signaling events mediated by Gli proteins | pid | 49 |
| Foxa2 | Regulation of gene expression in beta cells | reactome | 17 |
| Foxa2 | Maturity onset diabetes of the young | kegg | 25 |
| Foxa2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Foxa2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| Foxa2 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Foxa2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04088 | chr5:147263197-147264197 | pancreas | pancreatic progenitor cell | NA |
| E_04089 | chr5:147263197-147264197 | pancreas | pancreatic progenitor cell | NA |
| E_04091 | chr5:147263567-147264052 | pancreas | pancreatic progenitor cell | NA |
| E_04080 | chr5:147263601-147264086 | pancreas | NA | NA |
| E_04081 | chr5:147263601-147264086 | pancreas | NA | NA |
Expression of Target Genes for the Enhancer