About Enhancer
| Enhancer ID: | E_04096 |
| Species: | Homo sapiens |
| Position : | chr10:63525013-63527013   |
| Year: | 2017 |
| Title: | ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 29326336 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat E6.1 |
| CVCL ID: | CVCL_0367 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Oncogenic TF enhancer mapping; target-gene functional validation |
| High Throughput Method: | TAL1-complex ChIP-seq; H3K27ac ChIP-seq; RNA-seq |
| Low Throughput Method: | ChIP-qPCR; luciferase reporter assay; TAL1 perturbation; qRT-PCR; cell-growth assays |
About Target Gene
| Target gene : | ARID5B |
About TF
| TF name : | TAL1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03180 | chr10:63525013-63527013 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03181 | chr10:63525013-63527013 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03182 | chr10:63525013-63527013 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_04041 | chr10:63525013-63527013 | blood / hematopoietic system | malignant cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer