About Enhancer
| Enhancer ID: | E_04097 |
| Species: | Homo sapiens |
| Position : | chr7:92384001-92385000   |
| Year: | 2025 |
| Title: | Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 40162972 |
| MONDO: | MONDO:0018874 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | MTM9) and AML-661 PDX |
| Cell Type: | myeloid progenitor cell / leukemic blast |
| Experiment Type: | Chromatin interaction assay; Enhancer chromatin-state assay; Enhancer hijacking analysis; Target-gene functional validation |
| High Throughput Method: | WGS; RNA-seq; scRNA-seq; 4C-seq; ATAC-seq; ACT-seq (H3K27ac; H3K4me1) |
| Low Throughput Method: | qRT-PCR; genomic breakpoint PCR; MNX1 shRNA knockdown; flow cytometry; PDX competitive fitness assay |
About Target Gene
| Target gene : | MNX1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
10 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04067 | chr7:92384001-92385000 | NA | hematopoietic precursor cell | acute myeloid leukemia |
| E_04082 | chr7:92384001-92385000 | NA | hematopoietic stem and progenitor cells (HSPCs) | acute myeloid leukemia with del(7)(q22q36) |
| E_04083 | chr7:92384001-92385000 | blood | myeloid progenitor cell / leukemic blast | acute myeloid leukemia |
| E_04084 | chr7:92384001-92385000 | bone marrow | myeloid progenitor cell / leukemic blast | acute myeloid leukemia |
| E_04098 | chr7:92384001-92385000 | bone marrow | myeloid progenitor cell / leukemic blast | acute myeloid leukemia |
| E_04099 | chr7:92384001-92385000 | blood | myeloid progenitors and leukemic blasts | acute myeloid leukemia with del(7)(q22q36) |
| E_04100 | chr7:92384001-92385000 | bone marrow | myeloid progenitors and leukemic blasts | acute myeloid leukemia with del(7)(q22q36) |
| E_04108 | chr7:92384001-92385000 | blood | myeloid progenitors and leukemic blasts | acute myeloid leukemia with del(7)(q22q36) |
| E_04109 | chr7:92384001-92385000 | bone marrow | myeloid progenitors and leukemic blasts | acute myeloid leukemia with del(7)(q22q36) |
| E_04114 | chr7:92384001-92385000 | blood | AML leukemic cells | acute myeloid leukemia with del(7q) |
Expression of Target Genes for the Enhancer