About Enhancer
| Enhancer ID: | E_04118 |
| Species: | Homo sapiens |
| Position : | chr14:106152156-106153203   |
| Year: | 2024 |
| Title: | Core regions in immunoglobulin heavy chain enhancers essential for survival of non-Hodgkin lymphoma cells are identified by a CRISPR interference screen. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Burkitt lymphoma (B-cell non-Hodgkin lymphoma) |
| PMID: | 38934080 |
| MONDO: | MONDO:0007243 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | study-wide validation also included DG-75, SUDHL4 and lymphoma samples |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | IGH 3∩RR core peak 1; dense tiling CRISPRi-defined essential enhancer; eRNA-producing region; causal control of translocated MYC and lymphoma-cell survival |
| High Throughput Method: | Tiling CRISPRi screen with NGS sgRNA quantification; chromatin-enriched RNA-seq |
| Low Throughput Method: | Individual-sgRNA CRISPRi; GFP growth-competition assay; RT-qPCR for eRNA/MYC; BCR surface immunostaining/flow cytometry; MYC-rescue framework |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04117 | chr14:106152156-106153203 | blood | B cell | Burkitt lymphoma (B-cell non-Hodgkin lymphoma) |
Expression of Target Genes for the Enhancer