About Enhancer
| Enhancer ID: | E_04124 |
| Species: | Homo sapiens |
| Position : | chr2:79165929-79165948   |
| Year: | 2019 |
| Title: | LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 31767869 |
| MONDO: | MONDO:0005575 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HT-29/LIM1215 mechanistic validation |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | clinical-expression association; lncRNA enhancer-complex mechanism; functional perturbation |
| High Throughput Method: | lncRNA expression microarray; TCGA/R2 transcriptomic analyses |
| Low Throughput Method: | qRT-PCR; ddPCR; in situ hybridization; REG1CP knockdown/rescue; FANCJ interaction/recruitment assays; xenograft |
About Target Gene
| Target gene : | REG3A |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04110 | chr2:79165929-79165948 | colon | malignant cell | colorectal cancer |
Expression of Target Genes for the Enhancer