About Enhancer
| Enhancer ID: | E_04126 |
| Species: | Mus musculus |
| Position : | chr5:147267297-147268497   |
| Year: | 2008 |
| Title: | Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 19141476 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | Primary pancreatic islets |
| Cell Type: | pancreatic islet cell |
| Experiment Type: | TF binding assay; Developmental enhancer occupancy assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Foxa2 ChIP-qPCR; developmental-stage ChIP; conditional Foxa1/Foxa2 ablation; RT-qPCR |
About Target Gene
| Target gene : | Pdx1 |
About TF
| TF name : | Foxa2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Foxa2 | FOXA1 transcription factor network | pid | 45 |
| Foxa2 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Foxa2 | Hedgehog signaling events mediated by Gli proteins | pid | 49 |
| Foxa2 | Regulation of gene expression in beta cells | reactome | 17 |
| Foxa2 | Maturity onset diabetes of the young | kegg | 25 |
| Foxa2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Foxa2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| Foxa2 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Foxa2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04127 | chr5:147267297-147268497 | pancreas | pancreatic islet cell | NA |
| E_03908 | chr5:147267336-147267640 | islet of Langerhans | pancreatic beta cell | NA |
| E_03935 | chr5:147267614-147267639 | liver | hepatocyte | NA |
| E_03928 | chr5:147267670-147267721 | liver | hepatocyte | NA |
| E_03929 | chr5:147267701-147267751 | liver | hepatocyte | NA |
Expression of Target Genes for the Enhancer