About Enhancer
| Enhancer ID: | E_04128 |
| Species: | Mus musculus |
| Position : | chr17:26829232-26829742   |
| Year: | 2016 |
| Title: | Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26787680 |
| Tissue: | heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | Cardiac Progenitor Cell |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | Nkx2-5 |
About TF
| TF name : | Des |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Des | Aurora B signaling | pid | 41 |
| Des | Striated Muscle Contraction | reactome | 34 |
| Des | Hypertrophic cardiomyopathy (HCM) | kegg | 78 |
| Des | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
| Des | Dilated cardiomyopathy | kegg | 85 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04009 | chr17:26829229-26831311 | heart | NA | NA |
Expression of Target Genes for the Enhancer