About Enhancer
| Enhancer ID: | E_04129 |
| Species: | Homo sapiens |
| Position : | chr12:7940709-7941994   |
| Year: | 2011 |
| Title: | A Tcf/Lef element within the enhancer region of the human NANOG gene plays a role in promoter activation. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21689639 |
| Cell Source: | HEK-293 |
| CVCL ID: | CVCL_0045 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | NANOG |
About TF
| TF name : | LEF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| LEF1 | Alzheimer disease-presenilin pathway | panther | 98 |
| LEF1 | Binding of TCF/LEF:CTNNB1 to target gene promoters | reactome | 7 |
| LEF1 | C-MYB transcription factor network | pid | 87 |
| LEF1 | Ca2+ pathway | reactome | 62 |
| LEF1 | Cadherin signaling pathway | panther | 147 |
| LEF1 | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 |
| LEF1 | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 |
| LEF1 | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 |
| LEF1 | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 |
| LEF1 | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 |
| LEF1 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| LEF1 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| LEF1 | Integrin-linked kinase signaling | pid | 46 |
| LEF1 | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 |
| LEF1 | Notch | netpath | 76 |
| LEF1 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| LEF1 | Repression of WNT target genes | reactome | 14 |
| LEF1 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| LEF1 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| LEF1 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| LEF1 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| LEF1 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| LEF1 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| LEF1 | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| LEF1 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 |
| LEF1 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 |
| LEF1 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 |
| LEF1 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| LEF1 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 |
| LEF1 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| LEF1 | TGF_beta_Receptor | netpath | 220 |
| LEF1 | Wnt | netpath | 118 |
| LEF1 | Wnt signaling pathway | panther | 250 |
| LEF1 | Wnt signaling pathway | kegg | 135 |
| LEF1 | Adherens junction | kegg | 70 |
| LEF1 | Melanogenesis | kegg | 100 |
| LEF1 | Pathways in cancer | kegg | 321 |
| LEF1 | Colorectal cancer | kegg | 63 |
| LEF1 | Endometrial cancer | kegg | 52 |
| LEF1 | Prostate cancer | kegg | 85 |
| LEF1 | Acute myeloid leukemia | kegg | 53 |
| LEF1 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
| LEF1 | Hs_Wnt_Signaling_Pathway_Netpath_WP363_78571 | wikipathways | 28 |
| LEF1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| LEF1 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04043 | chr12:7940709-7941994 | kidney | epithelial cell | NA |
Expression of Target Genes for the Enhancer