About Enhancer
| Enhancer ID: | E_04182 |
| Species: | Mus musculus |
| Position : | chr11:35178343-35180368   |
| Year: | 2014 |
| Title: | 5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25263596 |
| Cell Source: | Tet2-/- |
| Experiment Type: | TF-binding/chromatin assay; In vivo functional validation |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; Transgenic/LacZ assay |
About Target Gene
| Target gene : | Slit3 |
About TF
| TF name : | Sox2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Sox2 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Sox2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Sox2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| Sox2 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
| Sox2 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| Sox2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer