About Enhancer
| Enhancer ID: | E_04219 |
| Species: | Homo sapiens |
| Position : | chr8:127247950-127248600   |
| Year: | 2025 |
| Title: | Dynamic interaction of MYC enhancer RNA with YEATS2 protein regulates MYC gene transcription in pancreatic cancer. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 40216980 |
| MONDO: | MONDO:0005184 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | MIA PaCa-2 |
| CVCL ID: | CVCL_0428 |
| Cell Type: | pancreatic ductal cell |
| Cell Ontology ID: | CL:0002079 |
| Experiment Type: | Enhancer/eRNA functional validation; Functional perturbation assay; RNA-protein interaction assay; Chromatin occupancy assay |
| High Throughput Method: | Nascent RNA-seq; H3K27ac ChIP-seq reanalysis; H3K4me1 ChIP-seq reanalysis; ATAC-seq reanalysis |
| Low Throughput Method: | RT-qPCR; Click-iT nascent RNA capture; shRNA-mediated MYC-490-kb eRNA knockdown; MYC-490-kb eRNA overexpression; UV-RIP-qPCR; YEATS2 shRNA knockdown; ZZZ3 ChIP-qPCR; ChIP-IP; Immunoprecipitation; Western blot; In vitro RNA-binding assay; MTT assay; Wound-healing assay |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer