About Enhancer
| Enhancer ID: | E_04230 |
| Species: | Homo sapiens |
| Position : | chr7:117587146-117589449   |
| Year: | 2022 |
| Title: | Epigenome editing of the CFTR-locus for treatment of cystic fibrosis. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 34049825 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HT-29 |
| CVCL ID: | CVCL_0320 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; Endogenous enhancer perturbation |
| High Throughput Method: | DNase-seq (public genomic accessibility data integration) |
| Low Throughput Method: | CRISPR/dCas9-KRAB epigenome repression; CRISPRi; qRT-PCR; Western blot; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | CFTR |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer