About Enhancer
| Enhancer ID: | E_04239 |
| Species: | Homo sapiens |
| Position : | chr4:173516002-173519662   |
| Year: | 2023 |
| Title: | The NR2F2-HAND2 signaling axis regulates progesterone actions in the uterus at early pregnancy |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 37664846 |
| Tissue: | endometrium |
| Tissue Ontology ID: | UBERON:0001295 |
| Cell Source: | T-HESC immortalized human endometrial stromal cells |
| Cell Type: | endometrial stromal cell |
| Experiment Type: | Enhancer activation assay; orthologous enhancer functional validation; endogenous target-gene activation |
| High Throughput Method: | Mouse NR2F2 ChIP-seq and RNA-seq used to nominate the conserved enhancer |
| Low Throughput Method: | dCas9-VPR CRISPRa with two independent gRNAs; RT-qPCR |
About Target Gene
| Target gene : | HAND2 |
About TF
| TF name : | NR2F2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NR2F2 | FOXA1 transcription factor network | pid | 45 |
| NR2F2 | Regulation of Telomerase | pid | 70 |
| NR2F2 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| NR2F2 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer