About Enhancer
| Enhancer ID: | E_04260 |
| Species: | Mus musculus |
| Position : | chr15:61449862-61451562   |
| Year: | 2012 |
| Title: | Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 23118011 |
| MONDO: | MONDO:0005575 |
| Tissue: | intestine |
| Tissue Ontology ID: | UBERON:0000160 |
| Cell Source: | ApcMin/+ |
| Cell Type: | intestinal epithelial cell |
| Cell Ontology ID: | CL:0002563 |
| Experiment Type: | Endogenous enhancer deletion; in vivo tumor-susceptibility assay; Endogenous enhancer perturbation; Disease-variant functional analysis; In vivo functional validation |
| High Throughput Method: | GWAS |
| Low Throughput Method: | Homologous-recombination germline enhancer deletion; RT-qPCR; Tcf7l2 binding analysis; intestinal histology; ApcMin tumor-burden assay; Mouse genetic deletion/knock-in; In vivo phenotyping |
About Target Gene
| Target gene : | Myc |
About TF
| TF name : | Tcf7l2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tcf7l2 | Alzheimer disease-presenilin pathway | panther | 98 |
| Tcf7l2 | Angiogenesis | panther | 141 |
| Tcf7l2 | AP-1 transcription factor network | pid | 71 |
| Tcf7l2 | Binding of TCF/LEF:CTNNB1 to target gene promoters | reactome | 7 |
| Tcf7l2 | Ca2+ pathway | reactome | 62 |
| Tcf7l2 | Cadherin signaling pathway | panther | 147 |
| Tcf7l2 | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7l2 | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7l2 | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7l2 | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7l2 | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7l2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Tcf7l2 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| Tcf7l2 | ID | netpath | 38 |
| Tcf7l2 | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 |
| Tcf7l2 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Tcf7l2 | Repression of WNT target genes | reactome | 14 |
| Tcf7l2 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7l2 | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| Tcf7l2 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7l2 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | reactome | 20 |
| Tcf7l2 | Wnt | netpath | 118 |
| Tcf7l2 | Wnt signaling pathway | panther | 250 |
| Tcf7l2 | Wnt signaling pathway | kegg | 135 |
| Tcf7l2 | Adherens junction | kegg | 70 |
| Tcf7l2 | Melanogenesis | kegg | 100 |
| Tcf7l2 | Pathways in cancer | kegg | 321 |
| Tcf7l2 | Colorectal cancer | kegg | 63 |
| Tcf7l2 | Endometrial cancer | kegg | 52 |
| Tcf7l2 | Prostate cancer | kegg | 85 |
| Tcf7l2 | Acute myeloid leukemia | kegg | 53 |
| Tcf7l2 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04261 | chr15:61449862-61451562 | intestine | intestinal epithelial cell | colorectal cancer |
Expression of Target Genes for the Enhancer