About Enhancer
| Enhancer ID: | E_04262 |
| Species: | Mus musculus |
| Position : | chr12:103024800-103025800   |
| Year: | 2020 |
| Title: | Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | obesity |
| PMID: | 33382813 |
| MONDO: | MONDO:0011122 |
| Tissue: | hypothalamus |
| Tissue Ontology ID: | UBERON:0001898 |
| Cell Source: | Mouse primary neurons |
| Cell Type: | neuron |
| Cell Ontology ID: | CL:0000540 |
| Experiment Type: | Functional perturbation assay; Endogenous enhancer perturbation; In vivo functional validation |
| High Throughput Method: | RNA-seq |
| Low Throughput Method: | CRISPR Knockout, CRISPRi, RT-RT-qPCR; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | Pomc |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer