About Enhancer
| Enhancer ID: | E_04263 |
| Species: | Mus musculus |
| Position : | chr17:31670439-31671892   |
| Year: | 2018 |
| Title: | Promoter-enhancer looping and shadow enhancers of the mouse 汐A-crystallin locus. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 30404901 |
| Tissue: | lens of camera-type eye |
| Tissue Ontology ID: | UBERON:0000965 |
| Cell Source: | embryonic mouse lens/lens-derived cells |
| Cell Type: | lens epithelial cell |
| Cell Ontology ID: | CL:0002224 |
| Experiment Type: | Shadow-enhancer activity; promoter-enhancer looping; developmental reporter validation; Chromatin interaction assay |
| High Throughput Method: | RNA-seq/chromatin-profile integration |
| Low Throughput Method: | 3C; transgenic LacZ reporter assay; ChIP/ChIP-qPCR; qRT-PCR |
About Target Gene
| Target gene : | Cryaa |
About TF
| TF name : | Etv5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Etv5 | AndrogenReceptor | netpath | 167 |
| Etv5 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| Etv5 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| Etv5 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| Etv5 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| Etv5 | FOXM1 transcription factor network | pid | 43 |
| Etv5 | IL12 signaling mediated by STAT4 | pid | 33 |
| Etv5 | RANKL | netpath | 84 |
| Etv5 | RhoA signaling pathway | pid | 46 |
| Etv5 | Hs_Androgen_receptor_signaling_pathway_WP138_79958 | wikipathways | 27 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04264 | chr17:31670439-31671892 | lens of camera-type eye | lens fiber cell | NA |
| E_04265 | chr17:31670439-31671892 | lens of camera-type eye | lens epithelial cell | NA |
| E_04266 | chr17:31670439-31671892 | lens of camera-type eye | lens fiber cell | NA |
| E_04274 | chr17:31670439-31671892 | lens of camera-type eye | NA | NA |
| E_04275 | chr17:31670439-31671892 | lens of camera-type eye | NA | NA |
Expression of Target Genes for the Enhancer