About Enhancer
| Enhancer ID: | E_04267 |
| Species: | Mus musculus |
| Position : | chr2:119321593-119322529   |
| Year: | 2014 |
| Title: | Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGF汕 signaling to specify V2b interneurons in the spinal cord. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 24257627 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | 293T,Progenitor Cell |
| CVCL ID: | CVCL_0063 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; In vivo functional validation |
| Low Throughput Method: | ChIP-qPCR/ChIP; EMSA/gel-shift assay |
About Target Gene
| Target gene : | Dll4 |
About TF
| TF name : | Ascl1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Ascl1 | Notch-mediated HES/HEY network | pid | 48 |
| Ascl1 | Notch | netpath | 76 |
| Ascl1 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| Ascl1 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer