About Enhancer
| Enhancer ID: | E_04284 |
| Species: | Homo sapiens |
| Position : | chr15:67442496-67442696   |
| Year: | 2018 |
| Title: | The role of SMAD3 in the genetic predisposition to papillary thyroid carcinoma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | thyroid gland papillary carcinoma |
| PMID: | 29300379 |
| MONDO: | MONDO:0005075 |
| Tissue: | thyroid gland |
| Tissue Ontology ID: | UBERON:0002046 |
| Cell Source: | TPC-1 |
| CVCL ID: | CVCL_6298 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; allele-specific regulatory-variant assay |
| High Throughput Method: | Expression microarray; microarray |
| Low Throughput Method: | SNP-centered dual-luciferase reporter assay for rs17293632; SMAD3 siRNA knockdown; RT-qPCR; downstream SMAD3-network ChIP-qPCR (not enhancer-site ChIP); Luciferase reporter assay; Reporter assay |
About Target Gene
| Target gene : | SMAD3 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04282 | chr15:67441595-67443595 | thyroid gland | malignant cell | thyroid gland papillary carcinoma |
| E_04283 | chr15:67441595-67443595 | thyroid gland | malignant cell | thyroid gland papillary carcinoma |
| E_04285 | chr15:67442496-67442696 | thyroid gland | malignant cell | thyroid gland papillary carcinoma |
| E_04322 | chr15:67442496-67442696 | thyroid gland | thyroid follicular epithelial cell | thyroid gland papillary carcinoma |
| E_04325 | chr15:67442496-67442696 | thyroid gland | thyroid follicular epithelial cell | thyroid gland papillary carcinoma |
Expression of Target Genes for the Enhancer