About Enhancer
| Enhancer ID: | E_04298 |
| Species: | Homo sapiens |
| Position : | chr1:92567177-92569177   |
| Year: | 2016 |
| Title: | An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Adenoid Cystic Carcinoma |
| PMID: | 26829750 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; 3C |
About Target Gene
| Target gene : | TGFBR3 |
About TF
| TF name : | TP63 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TP63 | Activation of PUMA and translocation to mitochondria | reactome | 8 |
| TP63 | Direct p53 effectors | pid | 141 |
| TP63 | Huntington disease | panther | 113 |
| TP63 | p53 pathway by glucose deprivation | panther | 21 |
| TP63 | p53 pathway | panther | 39 |
| TP63 | P53 pathway feedback loops 1 | panther | 6 |
| TP63 | p53 pathway feedback loops 2 | panther | 42 |
| TP63 | p73 transcription factor network | pid | 80 |
| TP63 | Regulation of TP53 Activity through Association with Co-factors | reactome | 14 |
| TP63 | TP53 Regulates Metabolic Genes | reactome | 85 |
| TP63 | TP53 Regulates Transcription of Caspase Activators and Caspases | reactome | 12 |
| TP63 | TP53 Regulates Transcription of Death Receptors and Ligands | reactome | 12 |
| TP63 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | reactome | 19 |
| TP63 | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | reactome | 14 |
| TP63 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| TP63 | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
| TP63 | Hs_Focal_Adhesion_WP306_80308 | wikipathways | 26 |
| TP63 | Hs_TGF-beta_Receptor_Signaling_WP560_90187 | wikipathways | 28 |
| TP63 | Hs_Urea_cycle_and_metabolism_of_amino_groups_WP497_72142 | wikipathways | 8 |
| TP63 | Hs_Hypothetical_Craniofacial_Development_Pathway_WP3655_88473 | wikipathways | 5 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer