About Enhancer
| Enhancer ID: | E_04300 |
| Species: | Mus musculus |
| Position : | chr12:3941972-3942627   |
| Year: | 2020 |
| Title: | Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | obesity |
| PMID: | 33382813 |
| MONDO: | MONDO:0011122 |
| Tissue: | arcuate nucleus of hypothalamus |
| Tissue Ontology ID: | UBERON:0001932 |
| Cell Source: | arcuate nucleus POMC neurons |
| Cell Type: | pro-opiomelanocortin neuron |
| Cell Ontology ID: | CL:4042033 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; Endogenous enhancer perturbation; In vivo functional validation |
| Low Throughput Method: | Targeted nPE1 enhancer knockout mouse model; in situ hybridization; RT-qPCR; acute leptin challenge; chronic leptin infusion; food intake measurement; body weight phenotyping; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | Pomc |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01296 | chr12:3938522-3942093 | NA | NA | NA |
Expression of Target Genes for the Enhancer