About Enhancer
| Enhancer ID: | E_04324 |
| Species: | Homo sapiens |
| Position : | chr3:128603821-128604120   |
| Year: | 2014 |
| Title: | A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia with inv(3)(q21.3q26.2)/t(3;3)(q21.3;q26.2) |
| PMID: | 24703906 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | inv(3) AML and G2DHE BAC-transgenic hematopoietic models |
| Cell Type: | hematopoietic stem/progenitor cell |
| Experiment Type: | Genetic enhancer-hijacking validation |
| Low Throughput Method: | BAC transgenesis; enhancer deletion; leukemia phenotyping; RT-qPCR |
About Target Gene
| Target gene : | MECOM |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00340 | chr3:128603426-128604425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00392 | chr3:128603426-128604425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00418 | chr3:128603426-128604425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_03951 | chr3:128603821-128604120 | bone marrow | myeloid leukemia cell | acute myeloid leukemia with inv(3)(q21.3q26.2)/t(3;3)(q21.3;q26.2) |
| E_03979 | chr3:128603821-128604120 | bone marrow | myeloid leukemia cell | acute myeloid leukemia with inv(3)(q21.3q26.2)/t(3;3)(q21.3;q26.2) |
Expression of Target Genes for the Enhancer