About Enhancer
| Enhancer ID: | E_04326 |
| Species: | Homo sapiens |
| Position : | chr15:67458052-67458252   |
| Year: | 2018 |
| Title: | The role of SMAD3 in the genetic predisposition to papillary thyroid carcinoma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | thyroid gland papillary carcinoma |
| PMID: | 29300379 |
| MONDO: | MONDO:0005075 |
| Tissue: | thyroid gland |
| Tissue Ontology ID: | UBERON:0002046 |
| Cell Source: | B-CPAP |
| CVCL ID: | CVCL_0153 |
| Cell Type: | thyroid follicular epithelial cell |
| Experiment Type: | Enhancer activity assay; Allele-specific regulatory variant assay |
| High Throughput Method: | Expression microarray data integration; microarray |
| Low Throughput Method: | Dual-luciferase reporter assay using rs4562997-centered 100-200-bp fragments; allele comparison; RT-qPCR; Luciferase reporter assay; Reporter assay |
About Target Gene
| Target gene : | SMAD3 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04286 | chr15:67457151-67459151 | thyroid gland | malignant cell | thyroid gland papillary carcinoma |
| E_04287 | chr15:67457151-67459151 | thyroid gland | malignant cell | thyroid gland papillary carcinoma |
| E_04288 | chr15:67458052-67458252 | thyroid gland | malignant cell | thyroid gland papillary carcinoma |
| E_04289 | chr15:67458052-67458252 | thyroid gland | malignant cell | thyroid gland papillary carcinoma |
| E_04323 | chr15:67458052-67458252 | thyroid gland | thyroid follicular epithelial cell | thyroid gland papillary carcinoma |
Expression of Target Genes for the Enhancer