About Enhancer
| Enhancer ID: | E_04332 |
| Species: | Homo sapiens |
| Position : | chr3:70961242-70974816   |
| Year: | 2026 |
| Title: | Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Normal |
| PMID: | 41355963 |
| Tissue: | umbilical vein |
| Tissue Ontology ID: | UBERON:0002066 |
| Cell Source: | HUVEC-C |
| CVCL ID: | CVCL_2959 |
| Cell Type: | human umbilical vein endothelial cell |
| Experiment Type: | dCas9-KRAB CRISPRi loss-of-function, dual-luciferase reporter assay |
| High Throughput Method: | CUT&Tag(H3K27ac/H3K4me1/H3K4me3); ATAC-seq; RNA-seq; CUT&Tag |
| Low Throughput Method: | dual-luciferase reporter detection; CRISPRi lentiviral transduction; RT-qPCR; Western blot, immunofluorescence staining; CRISPRi |
About Target Gene
| Target gene : | FOXP1 |
About TF
| TF name : | FOXP1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer