About Enhancer
| Enhancer ID: | E_04334 |
| Species: | Mus musculus |
| Position : | chr12:114460000-114490000   |
| Year: | 2019 |
| Title: | Complex sex-biased antibody responses: estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Autoimmune Diseases |
| PMID: | 30407507 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | B Cell |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | TF-binding/chromatin assay; In vivo functional validation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; RT-qPCR/qPCR; Transgenic/LacZ assay |
About Target Gene
| Target gene : | Aicda |
About TF
| TF name : | Esr1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Esr1 | AndrogenReceptor | netpath | 167 |
| Esr1 | AP-1 transcription factor network | pid | 71 |
| Esr1 | ATF-2 transcription factor network | pid | 59 |
| Esr1 | Cellular roles of Anthrax toxin | pid | 25 |
| Esr1 | FOXA1 transcription factor network | pid | 45 |
| Esr1 | FOXM1 transcription factor network | pid | 43 |
| Esr1 | Leptin | netpath | 98 |
| Esr1 | LKB1 signaling events | pid | 43 |
| Esr1 | Nuclear Receptor transcription pathway | reactome | 51 |
| Esr1 | Nuclear signaling by ERBB4 | reactome | 25 |
| Esr1 | Plasma membrane estrogen receptor signaling | pid | 42 |
| Esr1 | Prolactin | netpath | 105 |
| Esr1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Esr1 | Regulation of Telomerase | pid | 70 |
| Esr1 | Signaling events mediated by HDAC Class II | pid | 58 |
| Esr1 | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| Esr1 | Tamoxifen Action Pathway | smpdb | 10 |
| Esr1 | Tamoxifen Metabolism Pathway | smpdb | 10 |
| Esr1 | TGF_beta_Receptor | netpath | 220 |
| Esr1 | Validated nuclear estrogen receptor alpha network | pid | 65 |
| Esr1 | Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 | wikipathways | 36 |
| Esr1 | Hs_Leptin_signaling_pathway_WP2034_89856 | wikipathways | 37 |
| Esr1 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| Esr1 | Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687 | wikipathways | 16 |
| Esr1 | Hs_Estrogen_signaling_pathway_WP712_78491 | wikipathways | 13 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01338 | chr12:114461575-114496377 | spleen | mature B cell | NA |
| E_01339 | chr12:114461575-114496377 | spleen | mature B cell | NA |
| E_01384 | chr12:114461575-114496377 | spleen | mature B cell | NA |
| E_01374 | chr12:114462800-114464200 | spleen | mature B cell | NA |
| E_01375 | chr12:114465285-114467786 | spleen | mature B cell | NA |
Expression of Target Genes for the Enhancer