About Enhancer
| Enhancer ID: | E_04338 |
| Species: | Homo sapiens |
| Position : | chr18:61533339-61545796   |
| Year: | 2017 |
| Title: | SERPINB2 is regulated by dynamic interactions with pause-release proteins and enhancer RNAs. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 28578223 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | MonoMac6,K-562 |
| CVCL ID: | CVCL_0004 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | SERPINB2 |
About TF
| TF name : | CDK9 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CDK9 | AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) | inoh | 173 |
| CDK9 | AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) | inoh | 173 |
| CDK9 | AndrogenReceptor | netpath | 167 |
| CDK9 | Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) | inoh | 236 |
| CDK9 | Elongation arrest and recovery | reactome | 32 |
| CDK9 | Formation of HIV-1 elongation complex containing HIV-1 Tat | reactome | 42 |
| CDK9 | Formation of HIV elongation complex in the absence of HIV Tat | reactome | 44 |
| CDK9 | Formation of RNA Pol II elongation complex | reactome | 44 |
| CDK9 | HIV elongation arrest and recovery | reactome | 32 |
| CDK9 | IL6 | netpath | 85 |
| CDK9 | Pausing and recovery of HIV elongation | reactome | 32 |
| CDK9 | Pausing and recovery of Tat-mediated HIV elongation | reactome | 30 |
| CDK9 | Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) | inoh | 178 |
| CDK9 | RNA Polymerase II Pre-transcription Events | reactome | 64 |
| CDK9 | RNA polymerase II transcribes snRNA genes | reactome | 70 |
| CDK9 | RNA Polymerase II Transcription Elongation | reactome | 42 |
| CDK9 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | reactome | 32 |
| CDK9 | Tat-mediated elongation of the HIV-1 transcript | reactome | 40 |
| CDK9 | Tat-mediated HIV elongation arrest and recovery | reactome | 30 |
| CDK9 | TNFalpha | netpath | 274 |
| CDK9 | TP53 Regulates Transcription of DNA Repair Genes | reactome | 61 |
| CDK9 | VEGF signaling pathway ( VEGF signaling pathway ) | inoh | 183 |
| CDK9 | Hs_IL-9_Signaling_Pathway_WP22_79264 | wikipathways | 11 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04339 | chr18:61533339-61545796 | blood / hematopoietic system | NA | NA |
Expression of Target Genes for the Enhancer