About Enhancer
| Enhancer ID: | E_04349 |
| Species: | Homo sapiens |
| Position : | chr20:21452815-21462458   |
| Year: | 2014 |
| Title: | EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Ewing Sarcoma |
| PMID: | 25453903 |
| MONDO: | MONDO:0012817 |
| Cell Source: | HeLa |
| CVCL ID: | CVCL_0030 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; 3C |
About Target Gene
| Target gene : | NKX2-2 |
About TF
| TF name : | ELF1 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ELF1 | Angiopoietin receptor Tie2-mediated signaling | pid | 50 |
| ELF1 | AP-1 transcription factor network | pid | 71 |
| ELF1 | IL2 signaling events mediated by STAT5 | pid | 30 |
| ELF1 | PDGF signaling pathway | panther | 113 |
| ELF1 | Regulation of retinoblastoma protein | pid | 67 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04350 | chr20:21452815-21462458 | NA | NA | Ewing Sarcoma |
Expression of Target Genes for the Enhancer