About Enhancer
| Enhancer ID: | E_04363 |
| Species: | Mus musculus |
| Position : | chr4:44520195-44520234   |
| Year: | 2009 |
| Title: | Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 19345119 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Lymphopoiesis B Cell |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; In vivo functional validation |
| Low Throughput Method: | ChIP-qPCR/ChIP; EMSA/gel-shift assay; Transgenic/LacZ assay |
About Target Gene
| Target gene : | Pax5 |
About TF
| TF name : | Irf8 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Irf8 | GMCSF-mediated signaling events | pid | 38 |
| Irf8 | Interferon alpha/beta signaling | reactome | 67 |
| Irf8 | Interferon gamma signaling | reactome | 88 |
| Irf8 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Irf8 | Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 | wikipathways | 10 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer