About Enhancer
| Enhancer ID: | E_04385 |
| Species: | Mus musculus |
| Position : | chr6:60769316-60772093   |
| Year: | 2026 |
| Title: | Neuronal titration of Snca via enhancer disruption mitigates disease onset in a Parkinson's disease mouse model. |
| Genome Build: | mm39 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Parkinson disease |
| PMID: | 41496593 |
| MONDO: | MONDO:0005180 |
| Tissue: | substantia nigra |
| Tissue Ontology ID: | UBERON:0002038 |
| Cell Source: | Genetically engineered C57BL/6J mice |
| Cell Type: | dopaminergic neuron |
| Cell Ontology ID: | CL:0000700 |
| Experiment Type: | In vivo causal neuronal enhancer disruption in a Parkinson disease mouse model |
| High Throughput Method: | Prior neuronal chromatin-accessibility/enhancer discovery; genomic regulatory analysis |
| Low Throughput Method: | CRISPR-Cas12a enhancer deletion; smFISH/RNAscope; immunohistochemistry; stereology; Western blot; alpha-synuclein PFF challenge; motor assays |
About Target Gene
| Target gene : | Snca |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer