About Enhancer
| Enhancer ID: | E_04402 |
| Species: | Homo sapiens |
| Position : | chr4:84277627-84281723   |
| Year: | 2018 |
| Title: | HPSE enhancer RNA promotes cancer progression through driving chromatin looping and regulating hnRNPU/p300/EGR1/HPSE axis. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | gastric cancer |
| PMID: | 29511351 |
| MONDO: | MONDO:0001056 |
| Cell Source: | AGS |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; 3C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | HPSE |
About TF
| TF name : | EGR1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| EGR1 | AP-1 transcription factor network | pid | 71 |
| EGR1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| EGR1 | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| EGR1 | ErbB1 downstream signaling | pid | 105 |
| EGR1 | Glucocorticoid receptor regulatory network | pid | 85 |
| EGR1 | Interferon alpha/beta signaling | reactome | 67 |
| EGR1 | Regulation of Androgen receptor activity | pid | 54 |
| EGR1 | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | pid | 80 |
| EGR1 | Signaling events mediated by PRL | pid | 23 |
| EGR1 | TCR | netpath | 261 |
| EGR1 | Trk receptor signaling mediated by PI3K and PLC-gamma | pid | 36 |
| EGR1 | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| EGR1 | Prion diseases | kegg | 34 |
| EGR1 | Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 | wikipathways | 28 |
| EGR1 | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| EGR1 | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer