About Enhancer
| Enhancer ID: | E_04423 |
| Species: | Homo sapiens |
| Position : | chr2:136608729-136608757   |
| Year: | 2011 |
| Title: | The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1ζ± binding site and increases lactase promoter activity. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21327791 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | Caco-2 |
| CVCL ID: | CVCL_0025 |
| Cell Type: | enterocyte-like epithelial cell line |
| Experiment Type: | Enhancer activity assay; TF binding assay; Allele-specific functional assay |
| Low Throughput Method: | Transient transfection; Luciferase reporter assay; deletion analysis; EMSA; DNA footprinting |
About Target Gene
| Target gene : | LCT |
About TF
| TF name : | POU2F1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU2F1 | AndrogenReceptor | netpath | 167 |
| POU2F1 | ATF-2 transcription factor network | pid | 59 |
| POU2F1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| POU2F1 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| POU2F1 | FOXA1 transcription factor network | pid | 45 |
| POU2F1 | Glucocorticoid receptor regulatory network | pid | 85 |
| POU2F1 | Regulation of Androgen receptor activity | pid | 54 |
| POU2F1 | RNA polymerase II transcribes snRNA genes | reactome | 70 |
| POU2F1 | RNA Polymerase III Abortive And Retractive Initiation | reactome | 41 |
| POU2F1 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | reactome | 28 |
| POU2F1 | Hs_Integrated_Cancer_Pathway_WP1971_82939 | wikipathways | 33 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04422 | chr2:136608729-136608757 | colon | enterocyte-like epithelial cell line | NA |
Expression of Target Genes for the Enhancer