About Enhancer
| Enhancer ID: | E_04453 |
| Species: | Homo sapiens |
| Position : | chr14:98541905-98544383   |
| Year: | 2021 |
| Title: | Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute leukemia of ambiguous lineage |
| PMID: | 34103329 |
| MONDO: | MONDO:0019460 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary lineage-ambiguous leukemia cells |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer hijacking assay; Chromatin interaction assay; Structural-variant regulatory assay |
| High Throughput Method: | WGS; RNA-seq; H3K27ac regulatory profiling; chromatin-conformation profiling; structural-variant analysis |
| Low Throughput Method: | DNA/RNA FISH; genomic validation; allele-specific expression validation |
About Target Gene
| Target gene : | BCL11B |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer