About Enhancer
| Enhancer ID: | E_04458 |
| Species: | Homo sapiens |
| Position : | chr13:94663320-94664200   |
| Year: | 2014 |
| Title: | ABCC4 copy number variation is associated with susceptibility to esophageal squamous cell carcinoma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | esophageal squamous cell carcinoma |
| PMID: | 24510239 |
| MONDO: | MONDO:0005580 |
| Tissue: | adrenal gland |
| Tissue Ontology ID: | UBERON:0002369 |
| Cell Source: | NCI-H295R |
| CVCL ID: | CVCL_0458 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, CNV functional assay; Disease-variant functional analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay, RT-RT-qPCR, siRNA |
About Target Gene
| Target gene : | ABCC4 |
About TF
| TF name : | GATA3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA3 | C-MYB transcription factor network | pid | 87 |
| GATA3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| GATA3 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA3 | Glucocorticoid receptor regulatory network | pid | 85 |
| GATA3 | IL27-mediated signaling events | pid | 26 |
| GATA3 | Notch signaling pathway | pid | 58 |
| GATA3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| GATA3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| GATA3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer