About Enhancer
| Enhancer ID: | E_04461 |
| Species: | Mus musculus |
| Position : | chr3:34645597-34646134   |
| Year: | 2011 |
| Title: | The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21185279 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | Mouse Embryos |
| Experiment Type: | TF-binding/chromatin assay; In vivo functional validation |
| Low Throughput Method: | ChIP-qPCR/ChIP; EMSA/gel-shift assay |
About Target Gene
| Target gene : | Sox2 |
About TF
| TF name : | Pou5f1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pou5f1 | HIF-2-alpha transcription factor network | pid | 34 |
| Pou5f1 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Pou5f1 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Pou5f1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Pou5f1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Pou5f1 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer