About Enhancer
| Enhancer ID: | E_04468 |
| Species: | Homo sapiens |
| Position : | chr6:37997692-38001538   |
| Year: | 2018 |
| Title: | Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | Breast Cancer |
| PMID: | 30139998 |
| MONDO: | MONDO:0007254 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | T-47D |
| CVCL ID: | CVCL_0553 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq; ATAC-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | FOXA1 |
About TF
| TF name : | RNF2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RNF2 | Oxidative Stress Induced Senescence | reactome | 120 |
| RNF2 | SUMOylation of DNA damage response and repair proteins | reactome | 76 |
| RNF2 | SUMOylation of RNA binding proteins | reactome | 46 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer