About Enhancer
| Enhancer ID: | E_04471 |
| Species: | Homo sapiens |
| Position : | chr11:45868494-45868510   |
| Year: | 2017 |
| Title: | Potential contribution of tandem circadian enhancers to nonlinear oscillations in clock gene expression. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 28637769 |
| Cell Source: | U2OS |
| CVCL ID: | CVCL_0042 |
| Cell Type: | osteosarcoma cell line |
| Experiment Type: | Enhancer activity assay; TF binding assay; Circadian regulatory-element dissection assay |
| Low Throughput Method: | Luciferase reporter deletion/mutagenesis; real-time bioluminescence monitoring; ARNTL/CLOCK transactivation; EMSA; DNA-binding assay |
About Target Gene
| Target gene : | CRY2 |
About TF
| TF name : | CLOCK |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CLOCK | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| CLOCK | Circadian Clock | reactome | 49 |
| CLOCK | Circadian clock system | panther | 9 |
| CLOCK | Circadian rhythm pathway | pid | 17 |
| CLOCK | HATs acetylate histones | reactome | 142 |
| CLOCK | NR1D1 (REV-ERBA) represses gene expression | reactome | 8 |
| CLOCK | PPARA activates gene expression | reactome | 113 |
| CLOCK | RORA activates gene expression | reactome | 27 |
| CLOCK | Circadian rhythm - mammal | kegg | 19 |
| CLOCK | Circadian rhythm - fly | kegg | 7 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer