About Enhancer
| Enhancer ID: | E_04495 |
| Species: | Homo sapiens |
| Position : | chr11:69468873-69470873   |
| Year: | 2013 |
| Title: | TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Breast Tumor |
| PMID: | 23637611 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Disease-associated enhancer analysis |
| Low Throughput Method: | ChIP-qPCR/ChIP; 3C |
About Target Gene
| Target gene : | CCND1 |
About TF
| TF name : | KAT5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| KAT5 | Alzheimer disease-amyloid secretase pathway | panther | 56 |
| KAT5 | Alzheimer disease-presenilin pathway | panther | 98 |
| KAT5 | AndrogenReceptor | netpath | 167 |
| KAT5 | ATF-2 transcription factor network | pid | 59 |
| KAT5 | ATM pathway | pid | 34 |
| KAT5 | C-MYC pathway | pid | 25 |
| KAT5 | DNA Damage/Telomere Stress Induced Senescence | reactome | 64 |
| KAT5 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| KAT5 | G2/M DNA damage checkpoint | reactome | 84 |
| KAT5 | HATs acetylate histones | reactome | 142 |
| KAT5 | HDR through Homologous Recombination (HRR) | reactome | 46 |
| KAT5 | HDR through Single Strand Annealing (SSA) | reactome | 37 |
| KAT5 | Homologous DNA Pairing and Strand Exchange | reactome | 25 |
| KAT5 | IL9 | netpath | 24 |
| KAT5 | Nonhomologous End-Joining (NHEJ) | reactome | 69 |
| KAT5 | p53 pathway | pid | 59 |
| KAT5 | p73 transcription factor network | pid | 80 |
| KAT5 | Presynaptic phase of homologous DNA pairing and strand exchange | reactome | 39 |
| KAT5 | Processing of DNA double-strand break ends | reactome | 98 |
| KAT5 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | reactome | 75 |
| KAT5 | Regulation of Androgen receptor activity | pid | 54 |
| KAT5 | Regulation of TP53 Activity through Phosphorylation | reactome | 89 |
| KAT5 | Resolution of D-loop Structures through Holliday Junction Intermediates | reactome | 33 |
| KAT5 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | reactome | 26 |
| KAT5 | Sensing of DNA Double Strand Breaks | reactome | 6 |
| KAT5 | Validated targets of C-MYC transcriptional activation | pid | 80 |
| KAT5 | Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 | wikipathways | 50 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer