About Enhancer
| Enhancer ID: | E_04506 |
| Species: | Mus musculus |
| Position : | chr6:88180000-88180500   |
| Year: | 2021 |
| Title: | Conditionally pathogenic genetic variants of a hematopoietic disease-suppressing enhancer. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 34890222 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Hematopoietic stem cells, HSPCs |
| Cell Type: | hematopoietic stem cell |
| Cell Ontology ID: | CL:0000037 |
| Experiment Type: | Regulatory element functional validation, in vivo mouse model validation; Endogenous enhancer perturbation; Disease-variant functional analysis |
| Low Throughput Method: | CRISPR-Cas9 point mutation, RT-RT-qPCR, flow cytometry, competitive bone marrow transplantation; Site-directed/motif mutagenesis |
About Target Gene
| Target gene : | Gata2 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer