About Enhancer
| Enhancer ID: | E_04508 |
| Species: | Mus musculus |
| Position : | chr2:122651534-122668846   |
| Year: | 2018 |
| Title: | Dynamic transcriptional control of macrophage miRNA signature via inflammation responsive enhancers revealed using a combination of next generation sequencing-based approaches. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 29133016 |
| Cell Source: | Macrophage |
| Cell Type: | macrophage |
| Cell Ontology ID: | CL:0000235 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay |
| High Throughput Method: | ChIP-seq; ATAC-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; 3C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | Tlr4 |
About TF
| TF name : | Junb |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Junb | AP-1 transcription factor network | pid | 71 |
| Junb | ATF-2 transcription factor network | pid | 59 |
| Junb | BCR | netpath | 161 |
| Junb | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Junb | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| Junb | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| Junb | IL6-mediated signaling events | pid | 48 |
| Junb | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| Junb | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | reactome | 32 |
| Junb | TGF-beta signaling pathway | panther | 88 |
| Junb | TGF_beta_Receptor | netpath | 220 |
| Junb | TNFalpha | netpath | 274 |
| Junb | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| Junb | Hs_Kit_receptor_signaling_pathway_WP304_78799 | wikipathways | 46 |
| Junb | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04509 | chr2:122651534-122668846 | NA | macrophage | NA |
Expression of Target Genes for the Enhancer