About Enhancer
| Enhancer ID: | E_04513 |
| Species: | Homo sapiens |
| Position : | chr8:130180217-130180629   |
| Year: | 2017 |
| Title: | RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 28790107 |
| MONDO: | MONDO:0004963 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | human and mouse T-ALL models |
| Cell Type: | T-lineage leukemia cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | TF requirement for oncogenic enhancer activity and accessibility |
| High Throughput Method: | ChIP-seq; ATAC-based chromatin profiling; RNA expression profiling |
| Low Throughput Method: | RUNX1 deletion/perturbation; ChIP-qPCR; ATAC-qPCR; enhancer functional assays; leukemia growth assays |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | RUNX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RUNX1 | AndrogenReceptor | netpath | 167 |
| RUNX1 | Organic cation transport | reactome | 9 |
| RUNX1 | RANKL | netpath | 84 |
| RUNX1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| RUNX1 | TGF_beta_Receptor | netpath | 220 |
| RUNX1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| RUNX1 | Pathways in cancer | kegg | 321 |
| RUNX1 | Chronic myeloid leukemia | kegg | 69 |
| RUNX1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
67 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02010 | chr8:130179643-130181490 | blood / hematopoietic system | T cell | T-cell acute lymphoblastic leukemia |
| E_00455 | chr8:130180012-130180748 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01422 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01423 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01424 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01425 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01426 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01427 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01428 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01429 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01435 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01436 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01437 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01438 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01980 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01981 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01982 | chr8:130180065-130180972 | thymus | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01983 | chr8:130180065-130180972 | thymus | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01988 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01989 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01990 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01991 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01992 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01993 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01994 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01995 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01996 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01997 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01998 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01999 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_02000 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_02001 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_02002 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_02003 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_02007 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02008 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03525 | chr8:130180065-130180972 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03541 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03542 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03545 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03546 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03547 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03548 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03549 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03577 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_04520 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_04526 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04527 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04528 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04529 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01368 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01369 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01414 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01415 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01416 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01417 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01418 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01419 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01420 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01421 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_03543 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03544 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03551 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03552 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03553 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03554 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04512 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer