About Enhancer
| Enhancer ID: | E_04536 |
| Species: | Mus musculus |
| Position : | chr14:67742375-67743103   |
| Year: | 2011 |
| Title: | The gonadotropin-releasing hormone cell-specific element is required for normal puberty and estrous cyclicity. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21368045 |
| Tissue: | gonad |
| Tissue Ontology ID: | UBERON:0000991 |
| Cell Source: | Epithelial Cell,Granulosa Cells,GT1-7,GN11,Embryonic Stem Cell |
| Experiment Type: | Enhancer activity assay; In vivo functional validation |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay |
About Target Gene
| Target gene : | Gnrh1 |
About TF
| TF name : | Gata4 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata4 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata4 | Notch-mediated HES/HEY network | pid | 48 |
| Gata4 | Physiological factors | reactome | 12 |
| Gata4 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | reactome | 13 |
| Gata4 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Gata4 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Gata4 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Gata4 | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer