About Enhancer
| Enhancer ID: | E_04537 |
| Species: | Mus musculus |
| Position : | chr14:67742375-67743103   |
| Year: | 2011 |
| Title: | The gonadotropin-releasing hormone cell-specific element is required for normal puberty and estrous cyclicity. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21368045 |
| Tissue: | gonad |
| Tissue Ontology ID: | UBERON:0000991 |
| Cell Source: | Epithelial Cell,Granulosa Cells,GT1-7,GN11,Embryonic Stem Cell |
| Experiment Type: | Enhancer activity assay; In vivo functional validation |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay |
About Target Gene
| Target gene : | Gnrh1 |
About TF
| TF name : | Pou2f1 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Pou2f1 | AndrogenReceptor | netpath | 167 |
| Pou2f1 | ATF-2 transcription factor network | pid | 59 |
| Pou2f1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Pou2f1 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| Pou2f1 | FOXA1 transcription factor network | pid | 45 |
| Pou2f1 | Glucocorticoid receptor regulatory network | pid | 85 |
| Pou2f1 | Regulation of Androgen receptor activity | pid | 54 |
| Pou2f1 | RNA polymerase II transcribes snRNA genes | reactome | 70 |
| Pou2f1 | RNA Polymerase III Abortive And Retractive Initiation | reactome | 41 |
| Pou2f1 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | reactome | 28 |
| Pou2f1 | Hs_Integrated_Cancer_Pathway_WP1971_82939 | wikipathways | 33 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer