About Enhancer
| Enhancer ID: | E_04538 |
| Species: | Mus musculus |
| Position : | chrX:7954360-7956360   |
| Year: | 2011 |
| Title: | Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21464046 |
| Tissue: | heart |
| Tissue Ontology ID: | UBERON:0000948 |
| Cell Source: | Embryonic Stem Cell |
| Experiment Type: | Enhancer activity assay; In vivo functional validation |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay |
About Target Gene
| Target gene : | Gata1 |
About TF
| TF name : | Nkx2-5 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Nkx2-5 | Physiological factors | reactome | 12 |
| Nkx2-5 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Nkx2-5 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Nkx2-5 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer