Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_04540
Species: Mus musculus
Position : chr5:28563148-28563921
Year: 2022
Title: Cohesin is required for long-range enhancer action at the Shh locus.
Genome Build: mm10
Enhancer Type: Enhancer
Condition: Normal
PMID:  36097291
Tissue: neural tube
Tissue Ontology ID: UBERON:0001049
Cell Source: ES-E14
CVCL ID: CVCL_C320
Cell Type: embryonic stem cell
Cell Ontology ID: CL:0002322
Experiment Type: Synthetic enhancer activation assay; Cohesin functional perturbation assay; Chromatin conformation analysis
High Throughput Method: Hi-C data reanalysis; virtual 4C
Low Throughput Method: TALE-VP64 synthetic enhancer activation; auxin-inducible SCC1/RAD21 degradation; RNA FISH; DNA FISH
About Target Gene
Target gene : Shh
About TF
TF name : NA
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Enhancer Associated Network
Overlapping Enhancers (mm10) 2 found
Enhancer ID Position Tissue Cell Disease
E_01727 chr5:28561915-28564905 lung malignant cell NA
E_01728 chr5:28561915-28564905 lung malignant cell NA
Expression of Target Genes for the Enhancer