About Enhancer
| Enhancer ID: | E_04557 |
| Species: | Homo sapiens |
| Position : | chr8:128600697-128601159   |
| Year: | 2009 |
| Title: | Functional enhancers at the gene-poor 8q24 cancer-linked locus. |
| Genome Build: | hg18 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 19680443 |
| MONDO: | MONDO:0008315 |
| Tissue: | left supraclavicular lymph node |
| Tissue Ontology ID: | UBERON:8480056 |
| Cell Source: | LNCaP |
| CVCL ID: | CVCL_0395 |
| Cell Type: | epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Risk-variant functional assay; Disease-variant functional analysis |
| High Throughput Method: | Custom 8q24 tiling array; ChIP-chip; GWAS |
| Low Throughput Method: | DHT stimulation; TK-luciferase reporter assay; allele-specific reporter assay; FOXA1 ChIP-qPCR; EMSA; competition EMSA; rs11986220 allelic-binding assay; resequencing; Reporter assay |
About Target Gene
| Target gene : | NA |
About TF
| TF name : | FOXA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA1 | AndrogenReceptor | netpath | 167 |
| FOXA1 | Direct p53 effectors | pid | 141 |
| FOXA1 | FOXA1 transcription factor network | pid | 45 |
| FOXA1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg18)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_04556 | chr8:128600697-128601159 | left supraclavicular lymph node | epithelial cell | prostate cancer |
Expression of Target Genes for the Enhancer